Did You know Prolia Injection side effects and Prolia Injection cost?


iscover the potential side effects and cost considerations of Prolia Injection. Learn about the risks and expenses associated with Prolia Injection for osteoporosis treatment. Stay informed about Prolia Injection side effects and pricing to make informed healthcare decisions.

Prolia Injection side effects

Table of Contents

What is Prolia Injection?:

Prolia injection, a brand name for denosumab, stands as a pivotal treatment for osteoporosis, a condition characterized by weakened bones prone to fractures. As a healthcare provider, understanding the nuances of Prolia injection is paramount to effectively addressing osteoporosis in patients.

What is Denosumab in Prolia Injection:

“DENOSUMAB” is a very effective medicine that slows bone breakdown. Prolia and many other brands are used to treat osteoporosis, especially in women after menopause and in also men, or in people who have been taking corticosteroids for less than 6 months or longer. 

Prolia injection has been FDA-approved for 13 years more than 18 million women are treated with this injection worldwide. In 20 years the Prolia Injection clinical trial began. 

– Xgeva is used for patients who are suffering from high calcium levels due to cancer and this medicine prevents bone fractures and other joint and bone problems caused by multiple myeloma disease or bone cancer metastases. Xgeva is also useful for treating giant cell tumors of bone.

This medicine is also used for other purposes you must ask your healthcare provider (Doctor) or pharmacist if you have any further questions.

Other Denosumab Brand: XGEVA, Rozel, Amgen, Olimab and other.

How Does Prolia Injection Work?:

Mechanism of Action: Prolia injection operates by inhibiting bone breakdown. By targeting the RANK ligand, a protein involved in bone resorption, Prolia impedes the process of bone loss, thereby enhancing bone density and resilience.

Use Of Prolia Injection:

These are used only according to my research for the purpose.

  1. Osteoporosis
  2. Cancer-related conditions

1- Osteoporosis: It serves as a frontline treatment for osteoporosis in postmenopausal women and men, safeguarding against fractures and bolstering skeletal integrity.
2- Cancer-related Conditions: In cases where cancer leads to elevated calcium levels or bone metastases, Prolia injection, under the brand name Xgeva, offers therapeutic relief and prevents further bone complications.

Prolio Injection Cost:

The maximum retail price (MRP) of Prolia Injection depends on some factors such as the brand, dosage strength, and the region or country where it is being sold. but everyone knows very well in the USA or other countries Typically, pharmaceutical companies set the MRP based on production costs, doctor needs, market demand, regulatory requirements, and other factors.

As of recent data, the MRP for Prolia injection in the United States ranges from approximately The list price for Prolia injection is $1,736.63, per injection every six months. per dose. However, prices may vary in other countries due to differences in healthcare systems, pricing regulations, and currency exchange rates.

Patients need to consult with their healthcare provider or pharmacist to obtain accurate pricing information for Prolia injections in their specific location. Additionally, individuals may be eligible for insurance coverage, discounts, or patient assistance programs to help offset the cost of this medication.

Drug Interactions:

Prolia injection may interact with some medicines, precaution and close monitoring is required. also called drug-drug interactions  some interactions are written below:


Concurrent use of immunosuppressive agents may heighten the risk of infections, warranting vigilant surveillance.
List of some Immunosuppressants Medicines:

  • Cyclosporine
  • Tacrolimus
  • Sirolimus
  • Everolimus
  • Mycophenolate mofetil
  • Mizoribine
  • Leflunomide
  • Azathioprine


Concomitant administration of corticosteroids requires careful management to mitigate the potential for adverse reactions.
List of some steroid medicines:

  • Dexamethasone
  • Methylprednisolone
  • Prednisolone
  • Hydrocortisone
  • Betamethasone
  • Triamcinolone
  • Budesonide
  • Cortef
  • Deflazacort
Prolia Injection Side Effects

Prolia Injection Side Effects:

Prolia injection, while effective in treating osteoporosis, can potentially lead to various side effects in both men and women. Patients need to be aware of these potential adverse reactions and discuss any concerns with their healthcare provider. Here are some of the major side effects of Prolia injection, categorized by gender (If any symptoms show in any patient then must contact their Doctor or Pharmacist for further counteraction for these side effects).

Side Effects in Women:

  • Hypocalcemia: A common side effect shows of Prolia injection is low blood calcium levels, and doctors call this effect hypocalcemia. This can manifest as symptoms such as major muscle cramps, tingling and body sensations, and numbness in hands and feet.
  • Joint, or Muscle Pain: Some women may experience discomfort in their joints, bones, and muscles after taking a Prolia injection. The pain of the Prolio injection side effect can go from mild to severe and may require immediate medical attention if strong or severe.
  • Increased Risk of Infections: Prolia injection may weaken the body’s immune response, increasing the chance of infection. Women may experience infections more frequently, such as respiratory tract infections or urinary tract infections.
  • Skin Reactions: Some women may have skin reactions such as rash, itching, or redness at the injection site after a Prolia injection. These reactions are usually mild and resolve on their own but should be monitored for any signs of worsening.

Side Effects in Men:

  • Hypocalcemia: Like women, men receiving Prolia injections may experience low levels of calcium in the blood, but not every man or woman, which may result in symptoms such as muscle cramps, tingling, and numbness.
  • Back Pain: Men may experience back pain as a side effect of Prolia injection. This discomfort problem may vary at times or even be completely different and may require adjustments in pain management strategies or treatment regimens.
  • Urinary Tract Infections: Some men may have an increased risk of urinary tract infection or bacterial infection after Prolia injection. Symptoms may include a strong urge to urinate, pain or burning during urination, similar to a UTI infection, and cloudy or bloody urine. And if the organ is getting damaged then pus may also come out from it.
  • Fatigue: Fatigue or general weakness may occur in some men as a side effect of Prolia injection. This may affect daily activities and may require adjustments in lifestyle or treatment plans.

General Considerations:

  • Rare but Serious Side Effects: Although less common, Prolia injection may also be associated with serious side effects such as abnormal fractures of the thigh bone or osteonecrosis of the jaw. Patients should immediately inform their healthcare provider of any unusual symptoms.
  • Some Variation: It is important to note that not all patients will experience these side effects, and individual responses to Prolia injection may vary. Patients should discuss their medical history and any concerns with their healthcare provider before starting treatment.

In summary, while Prolia injection can effectively manage osteoporosis, patients should remain vigilant for potential side effects and seek medical attention if any concerns arise.

Some Common Side Effects of Prolia Injection:

These types of side effects do not require medical attention because these type of symptoms shows with many normal medicines. (report to your doctor or health care professional if they repeat again and again)

  • constipation
  • diarrhea
  • headache
  • joint pain
  • loss of appetite
  • muscle pain
  • runny nose
  • tiredness
  • upset stomach

Rx Warnings For Prolia Injection:

These warnings highlight important safety considerations associated with Prolia injection and should be discussed with healthcare providers before starting treatment.

  • Hypocalcemia: They cause a risk of low blood calcium levels, and also cause symptoms like muscle cramps and numbness.
  • Atypical Femoral Fractures: It is a rare case but serious risk of fractures in the thigh bone, if anyone uses this for long-term use.
  • Osteonecrosis of the Jaw: Potential for jawbone tissue damage, especially in some patients undergoing dental procedures after this.
  • Increased Infection Risk: Higher possibility of infections, like respiratory and UTI (urinary tract infections).
  • Skin Reactions: it’s common but possible skin reactions like rash or redness at the given site of injection.
  • Back Pain: Some patients reported discomfort in the back area as a common side effect.
  • Urinary Tract Infections: Elevated risk of UTI infection, and it’s especially and particularly in men.
  • Fatigue: Some patients may experience fatigue not every patient or weakness as a side effect.

These warnings highlight important safety considerations associated with Prolia injection and should be discussed with healthcare providers before starting treatment.

Frequently Asked Questions (FAQs): 

A1: If you receive Prolia, you should not receive XGEVA. Prolia contains the same medicine as XGEVA (denosumab).

A2: The most common side effects of Prolia in patients with corticosteroid-induced osteoporosis are back pain, high blood pressure, bronchitis, and headache.

A3: This medication has a long list of side effects and it is also important to note that the long-term risks are unknown. The FDA drug guide lists potential health problems, including serious infection, thigh bone fractures, and jaw bone problems. It is not clear whether the benefits outweigh the risks. 

A4: Fosamax and other is usually the first-choice option for osteoporosis. However, Prolia may be preferred in many people with very high fracture risk. The most common side effects of Boniva and Fosamax are GIT symptoms like acid reflux, nausea, vomiting, and diarrhea.

A4: Regular dental check-ups are essential for professional cleanings and early detection of potential issues. Dentists can provide personalized advice and treatments to maintain optimal oral health.



Prolia Injection side effects and cost

-Please remember, to always consult with healthcare professionals or Doctors for personalized advice related to medical conditions.


Understanding the nuances of Prolia injection, including its mechanism of action and drug interactions, is paramount for healthcare providers to effectively address osteoporosis in patients. The medication’s efficacy in treating osteoporosis, especially in postmenopausal women and men, underscores its importance in preventing fractures and maintaining skeletal integrity.

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Rahul Priydarss

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