Myasthenia Gravis (MG) is a chronic autoimmune disorder that affects the neuromuscular junction, leading to muscle weakness and fatigue.
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Genetic Predisposition
Certain genetic factors may increase the likelihood of developing Myasthenia Gravis, although the condition is not directly inherited.
Autoimmune Response
MG is primarily caused by an abnormal immune response where antibodies mistakenly attack acetylcholine receptors at the neuromuscular junction.
Thymus Gland Abnormalities
Many patients with MG have an abnormal thymus gland, which may produce antibodies that attack muscle receptors.
Infections
Viral or bacterial infections might trigger the onset of Myasthenia Gravis by initiating or exacerbating the autoimmune response.
Medications
Certain drugs, such as antibiotics, beta-blockers, and anesthetics, can worsen MG symptoms or potentially trigger the condition in predisposed individuals.
Pregnancy
Pregnancy can influence the course of Myasthenia Gravis, potentially triggering symptoms in women who are genetically predisposed to the condition.
Stress
Physical or emotional stress may exacerbate MG symptoms or trigger the onset of the disease by affecting the immune system.
Hormonal Changes
Fluctuations in hormones, especially during puberty, pregnancy, or menopause, may contribute to the onset or worsening of MG.
Autoimmune Disorders
Individuals with other autoimmune diseases, such as rheumatoid arthritis or lupus, may be at a higher risk of developing MG.
Environmental Factors
Exposure to certain environmental toxins or chemicals might play a role in triggering Myasthenia Gravis in susceptible individuals.