Rahul priydarss
It’s a broad term describing widespread liver cell damage. Instead of one small lesion, the entire liver tissue is affected, often linked to chronic illness.
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The condition may result from viral hepatitis (B or C), chronic alcohol use, fatty liver disease, autoimmune hepatitis, or certain toxic exposures.
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Most patients notice only mild fatigue, poor appetite, or slight abdominal discomfort in early stages, making early detection tricky.
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If untreated, it can progress to jaundice, swelling in the abdomen (ascites), easy bruising, and confusion (hepatic encephalopathy).
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Ultrasound, CT, and MRI often reveal diffuse liver texture changes. Radiologists look for patterns like fibrosis, fatty infiltration, or cirrhosis.
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Abnormal liver function tests (LFTs) — such as high ALT, AST, bilirubin, or low albumin — are key markers of diffuse hepatocellular disease.
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Unlike localized liver tumors, diffuse disease affects the whole liver, meaning management focuses on slowing progression rather than removing a single mass.
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Alcohol, obesity, and poor diet speed up liver damage. Lifestyle changes like balanced diet, exercise, and avoiding alcohol can significantly slow the disease.
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Management may include antiviral therapy (for hepatitis), lifestyle modification, medications to reduce inflammation, and in advanced cases, liver transplantation.
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Regular health checkups, vaccination against hepatitis B, controlling diabetes, and maintaining a healthy weight are the best defenses against diffuse hepatocellular disease.