Is Gestational Trophoblastic Disease Hereditary

What Is Gestational Trophoblastic Disease (GTD)?

A rare group of pregnancy-related tumors that start in the cells that form the placenta.

Is GTD a Type of Cancer?

Some forms, like choriocarcinoma, are malignant—but others are non-cancerous and highly treatable.

Any Genetic Link in GTD?

Although rare, familial recurrent hydatidiform moles can be inherited due to gene mutations like NLRP7.

Who’s at Higher Risk?

Women under 20 or over 35, and those with a history of molar pregnancy, have a higher GTD risk.

Are Daughters at Risk If Mothers Had GTD?

No clear evidence shows GTD passes from mother to daughter, except in extremely rare inherited cases.

What Causes GTD?

Most cases result from abnormal fertilization—not from inherited traits or family history.

How Common Is Inherited GTD?

Less than 1 in 1,000,000 cases are genetic. Most GTD cases are isolated and not passed down.

Should I Get Genetic Testing for GTD?

Not usually needed, unless you've had multiple molar pregnancies—then genetic counseling may help.

Bottom Line: GTD Isn’t Typically Inherited

For most women, GTD is not genetic and does not increase inherited risk for family members.

Is Gestational Trophoblastic Disease Hereditary?

No, GTD is not considered hereditary in most cases. It usually happens sporadically.

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