Tay Sachs Disease

What is Tay-Sachs Disease?

A rare genetic disorder that destroys nerve cells in the brain and spinal cord, leading to severe neurological problems.

Early Warning Signs Parents Shouldn’t Ignore

– Loss of motor skills (crawling, sitting) – Increased startle response – Vision and hearing lo – Weak muscles and paralysi

The Science Behind Tay-Sachs: What Happens in the Body?

A missing enzyme (Hexosaminidase A) causes a toxic buildup of fats (GM2 ganglioside) in the brain, leading to nerve cell damage.

Who is at Risk? Genetic Factors You Must Know

– Most common in Ashkenazi Jews, French Canadians, Cajuns, and some Irish populations. – A child inherits two faulty HEXA genes (one from each parent).

How is Tay-Sachs Diagnosed?

Blood test to check HEXA enzyme level Genetic screening for high-risk familie Prenatal testing for early detection

Is There a Cure for Tay-Sachs? The Latest Research

Currently, there is no cure, but gene therapy, enzyme replacement, and stem cell research offer hope for future treatments.

Life Expectancy and Disease Progression

– Symptoms appear at 3-6 month – Progressive loss of movement and function – Most children do not survive past age 4-5 year

How Carrier Screening Can Save Live

– A simple genetic test before pregnancy can detect carriers. Carrier couples can explore IVF with genetic screening to prevent passing on the disease.

Coping with a Tay-Sachs Diagnosi

– Seek support groups (NTSAD, Cure Tay-Sachs Foundation) – Explore palliative care for symptom management – Lean on family and community for emotional strength

How to Spread Awareness and Support Research

– Participate in fundraising walks & campaign – Advocate for genetic testing awarene – Support research initiatives for potential treatment

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